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                首頁 > 產品中心 > 抗體 > 二抗 > abs131127Rabbit anti-Twist1 Polyclonal Antibody

                Rabbit anti-Twist1 Polyclonal Antibody

                簡要描述:Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 th

                • 產品型號:abs131127
                • 廠商性質:生產廠家
                • 更新時間:2025-06-13
                • 訪  問  量:1288

                詳細介紹

                品牌absin供貨周期現貨
                應用領域化工,生物產業,能源
                概述
                描述
                Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
                別名
                Twist1抗體;ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; OTTHUMP00000116043; SCS; TWIST; Twist basic helix loop helix transcription factor 1; Twist family bHLH transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; TWIST1; TWST1_HUMAN;
                宿主
                Rabbit
                特異性
                The antibody detects endogenous levels of total Twist1 protein.
                反應種屬
                Human;Mouse;Rat
                應用
                WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
                免疫原
                A synthesized peptide derived from Human TWIST1(Accession Q15672), corresponding to amino acid residues M1-P24.
                性能
                濃度
                1mg/ml
                純化方法
                The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
                類型
                Polyclonal Antibody
                儲存/保存方法
                Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
                存儲溶液
                Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
                靶標
                背景說明
                Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
                組織特異性
                Subset of mesodermal cells.
                細胞定位
                Nucleus;
                UniProt
                Q15672
                實驗結果圖
                Western blot analysis of extracts from JK, Raji and HL-60 cells using Twist1 Antibody
                溫馨提示:本產品僅作科研實驗使用,不支持臨床等研究

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