全國服務咨詢熱線:

                15000105423

                Products產品中心
                首頁 > 產品中心 > 生化試劑 > 其它生化試劑 > abs42024900百日咳毒素PTX,Pertussis Toxin

                百日咳毒素PTX,Pertussis Toxin

                簡要描述:百日咳毒素是由細菌Bordetella pertussis產生的,以蛋白質為基礎的AB5型外毒素。是特定靶向G蛋白抑制G蛋白及其在信號通路中的生理功能,在傳染方面發揮重要作用;還能在鼠類動物中刺激建立實驗性自身免疫疾病模型。

                • 產品型號:abs42024900
                • 廠商性質:生產廠家
                • 更新時間:2025-06-13
                • 訪  問  量:4843

                詳細介紹

                品牌absinCAS70323-44-3
                分子式-純度>99%
                分子量-貨號abs42024900
                規格50ug供貨周期現貨
                主要用途特定靶向G蛋白抑制G蛋白及其在信號通路中的生理功能應用領域醫療衛生,環保,化工,生物產業,農林牧漁
                產品描述
                描述

                Pertussis Toxin (islet-activating protein), a toxin originally isolated from Bordetella pertussis, has been shown to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.

                應用
                A toxin that blocks reduction of adenylate cyclase activity
                純度
                >99%
                活性
                Please note that this product is not activated. If your system requires activation, see Kaslow et al.,for suggested conditions.
                使用方法
                CHO Cell Assay: When examined in a CHO cell assay as described by Hewlett et al.,5 the lowest concentration of toxin at which a positive response (clustered growth pattern) was obtained was 0.01 ng/ml.

                Adenylate Cyclase Assay: The adenylate cyclase activity of this lot is 0.67 picomole/min/lJg in the presence of 1 μmolar calmodulin when assayed by the method of Wolff et al6
                儲存/保存方法
                This product is provided as an aseptically packaged lyophilized powder, sealed under vacuum. Store at 4°C prior to and following reconstitution, for 6 months. DO NOT FREEZE.
                基本信息
                外觀
                Lyophilized solid
                可溶性/溶解性
                Soluble in water (Miscible). Reconstitute with sterile purified water or the sterile buffer of your choice. The resulting suspension should be made uniform by gentle mixing prior to use. Do not sterile filter, as this will result in loss of material. For long term storage, reconstitute in a high ionic strength buffer, such as sterile 0.1 M sodium phosphate, pH 7.0, 0.5 M NaCI. Handle the product gently; do not vortex.
                參考文獻
                參考文獻
                1. Bradford, M.M. (1976) Anal. Biochem. 72, 248-254.
                2. Tamura, M., Nogomori, K., Murai, S., Yajima, M., Ito, K" Katada, T., Ui, M. and Ishi, S. (1982) Biochem. 21,5516-5522.
                3. Wyckoff, M., Rodbard, O. And Chramback, A. (1977) Anal. Biochem.78, 459-482.
                4. Laemmli, U.K. (1970) Nature 227, 680-685.
                5. Hewlett, E.L., Sauer, K.T., Myers, G.A., Cowell, J.L. and Guerrant, R.L. (1983) Infect. Immun. 40, 1198-1203.
                6. Wolff, J., Cook, G.H., Goldhammer, A.R. and Berkowitz, S.A. (1980) PNAS 77, 3841-3844.
                7. Kaslow, H.R., Lim, L.-K., Moss, J. and Lesikar, D.O. (1987) Biochem. 26, 123-127.

                產品咨詢

                留言框

                • 產品:

                • 您的單位:

                • 您的姓名:

                • 聯系電話:

                • 常用郵箱:

                • 省份:

                • 詳細地址:

                • 補充說明:

                • 驗證碼:

                  請輸入計算結果(填寫阿拉伯數字),如:三加四=7
                愛必信(上海)生物科技有限公司
                地址:上海市浦東新區新浩路58號申江科創園18棟
                郵箱:chenjw@absin.cn
                傳真:
                關注我們
                歡迎您關注我們的微信公眾號了解更多信息:
                歡迎您關注我們的微信公眾號
                了解更多信息
                主站蜘蛛池模板: 国产挤奶水主播在线播放| 好吊妞在线观看| 精品久久中文网址| 中国毛片免费观看| 国产偷窥女洗浴在线观看| 在线观看www日本免费网站| 无码专区人妻系列日韩精品| 欧美一级日韩一级亚洲一级| 男女一边做一边爽免费视频| 香蕉视频软件app下载| 亚洲免费视频观看| 国产欧美日韩一区二区加勒比| 欧美精品综合一区二区三区 | 动漫无遮挡在线观看| 国产女人水多毛片18| 国产精品久久久久网站| 国产色无码专区在线观看| 国产高中生粉嫩无套第一次| 夜夜揉揉日日人人| 天天躁日日躁aaaaxxxx| 在厨房里被挺进在线观看| 最新国产午夜精品视频成人| 日本激情一区二区三区| 小草视频免费观看| 国产精品任我爽爆在线播放| 国产精品美女久久久久AV福利 | 百合h肉动漫无打码在线观看| 精品国产三级在线观看| 真实国产乱子伦高清| 皇夫被迫含玉势女尊高h| 狠狠色狠狠色合久久伊人| 丁香六月久久久| 高清一级淫片a级中文字幕| 97视频久久久| 韩国免费乱理论片在线观看2018| 精品久久久久久无码人妻热 | 国产一区二区三区视频| 午夜阳光电影在线观看| 免费被靠视频动漫| 亚洲区小说区激情区图片区| 中文天堂在线最新版在线www|