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                Rabbit anti-CD278/ICOS Recombinant Monoclonal Anti

                簡要描述:Rabbit anti-CD278/ICOS Recombinant Monoclonal Antibody(R104),儲存溶液:PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

                • 產品型號:abs171777
                • 廠商性質:生產廠家
                • 更新時間:2025-06-11
                • 訪  問  量:1368

                詳細介紹

                品牌absinCAS-
                分子式-純度-
                分子量-貨號abs171777
                規格100uL供貨周期現貨
                主要用途IHC-P: 1:500應用領域化工,生物產業,綜合
                概述
                別名
                Inducible T-cell costimulator; AILIM
                宿主
                Rabbit
                反應種屬
                Human
                應用
                IHC-P: 1:500
                性能
                形式
                Liquid
                濃度
                0.5 mg/ml
                純化方法
                Protein A affinity column
                類型
                Monoclonal Antibody
                克隆號
                R104
                儲存/保存方法
                Store at -20℃ for one year.
                存儲溶液
                PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
                靶標
                背景說明
                Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728].
                細胞定位
                Cell Membrane, Secreted
                UniProt
                Q9Y6W8
                實驗結果圖
                IHC shows positive staining in paraffin-embedded human thymus. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
                IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
                IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
                Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
                溫馨提示:本產品僅作科研實驗使用,不支持臨床等研究

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